Artículos y presentaciones en CongresosNo Descriptionhttps://digital.cic.gba.gob.ar/handle/11746/1172024-03-29T05:56:49Z2024-03-29T05:56:49Z581Actividad antimicrobiana de germicidas halogenados frente a aislamientos hospitalariosMagariños, María del CarmenPenacca, Alejandra C.Castelo, Sandra M.Martínez, Anabela M.Demartini, Eduardo A.Landriel, LorenaReynaldo, Mirta Beatrizhttps://digital.cic.gba.gob.ar/handle/11746/35112016-08-10T13:13:24Z2001-01-01T00:00:00Zdc.type: Artículo
dcterms.alternative: Antimicrobial activity of halogenated compounds against hospital microbial isolates
dcterms.isPartOf.*: vol. 20, no. 3; Acta Farmacéutica Bonaerense
dcterms.abstract: Antiseptics and disinfectants are extensively used in hospitals and health care settings for a variety of topical and hard-surface applications. In particular, they are essential part of infection control practices and in the prevention of nosocomial infections. Despite this, few is known about the mode of action of these biocides with respect to antibiotics. In general, the antimicrobial activity can be influenced by many factors such as formulation effects, presence of organic matter, synergy, temperature, dilution and test method. The widespread use of antiseptics and disinfectant products has prompted some speculation on the development of microbial resistance, in particular cross-resistance to antibiotics. The aim of this study was to evaluate microbiological resistance to halogenated compounds by studying the behaviour of the grampositive and gramnegative clinical isolates against halogenated biocides usually applied, with and without organic substance and applying distilled water, potable water and water of 300 ppm hardness as dilution means. The results indicate that the hospital microorganisms show a higher resistance to the biocides than the strain Staphylococcus aureus ATCC 6538, although the effective concentration in clean conditions was lesser than the recommended ones, for all the dilution means. In presence of organic matter the antimicrobial activity was reduced in accordance with the bactericidal concentration of each microorganisrn, due to the oxidant action of these disinfectants; Los antisépticos y desinfectantes se emplean en hospitales para una gran variedad de aplicaciones, tanto tópicas como sobre superficies. Estos compuestos son esenciales en el control y la prevención de las infecciones nosocomiales. A pesar de esto, se conoce bastante menos acerca del modo de acción de estos biocidas que de los antibióticos habitualmente empleados en terapéutica. La actividad antimicrobiana puede ser influenciada por muchos factores tales como la formulación, la presencia de materia orgánica, efectos de sinergia, temperatura, dilución e incluso del método de ensayo. El uso tan difundido de productos desinfectantes y antisépticos ha llevado a algunas especulaciones sobre el desarrollo de resistencia microbiana, y particularmente, resistencia cruzada con antibióticos. Con el propósito de estudiar la resistencia microbiana a germicidas halogenados de uso corriente en ,centros asistenciales, se evaluó el comportamiento de aislamientos hospitalarios tanto gram negativos como gram positivos frente a soluciones de hipoclorito de sodio, iodopovidona y tintura de iodo en presencia y ausencia de sustancias interferentes tales como materia orgánica y cationes. Los multados obtenidos indican que los microorganismos hospitalarios presentan mayor resistencia a los bioddas analizados con respecto al microorganismo de ref- erencia Staphylococcus aureus ATCC 6538. Sin embargo, en condiciones limpias este grupe de biocidas posee una alta eficacia, aún muy por debajo de las concentraciones de uso recomendadas, para todos los medios de dilución estudiados. Con la presencia de materia orgánica la actividad germicida disminuyó en todos los casos en relación directamente proporcional a la concentración, debido a la naturaleza predominantemente oxidante de estos compuestos.
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Reynaldo - Actividad.pdf-PDFA.pdf: 629797 bytes, checksum: b8129b722aee18b6c98ffe926cb17c1a (MD5)
dc.title: Actividad antimicrobiana de germicidas halogenados frente a aislamientos hospitalarios
2001-01-01T00:00:00ZAdolescentes bonaerenses institucionalizados por delitosWiese, RenataCatanesi, Cecilia InésFolino, Jorge OscarCalcena, Eugeniohttps://digital.cic.gba.gob.ar/handle/11746/53222017-03-13T13:57:45Z2016-12-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 6, nº 5; Tercera Época
dcterms.abstract: Publicaciones de la última década pusieron de manifiesto la escasez de investigación en la provincia de Buenos Aires sobre los adolescentes y sus conductas antisociales . Asimismo, destacaron la necesidad de disponer de instrumentos que permitan evaluar las vulnerabilidades y características sobre las que se pueda intervenir a los efectos de prevenir la persistencia en trayectorias delictuales. Con la meta de contribuir a completar esa información faltante se diseñó una amplia sistemática de evaluación con obtención de información sistematizada de las dimensiones biológica, psicológica y social. En este informe se describen aspectos de las dimensiones psicológica y social.
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dc.title: Adolescentes bonaerenses institucionalizados por delitos
2016-12-01T00:00:00ZAlteraciones inducidas por administración neonatal de monosodio L-glutamato (MSG) y su remisión mediante la administración de N-acetil cisteínaVillagarcía, Hernán GonzaloCastro, María CeciliaGonzáles Arbelaez, LuisaSchinella, Guillermo RaúlCastrogiovanni, DanielMassa, María LauraSpinedi, EduardoFrancini, Flaviohttps://digital.cic.gba.gob.ar/handle/11746/62482017-10-18T17:23:57Z2016-04-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 7, no. 1; Tercera Época
dcterms.abstract: La administración neonatal de monosodio L-glutamato (MSG) a ratas genera daño a nivel de neuronas del núcleo arcuato hipotalámico, lo cual determina en la adultez anormalidades morfológicas, neuroendocrinas y del comportamiento, similares a las observadas en el Síndrome Metabólico (SM) humano. Por otro lado, se reconoce un rol patogénico clave del estrés oxidativo en numerosas enfermedades, incluido el mencionado SM. En consecuencia, el objetivo del presente trabajo fue evaluar los efectos de la administración de N-acetil cisteína (NAC), un reconocido antioxidante, que además promueve el incremento en la síntesis de GSH, sobre las alteraciones ocasionadas por el tratamiento neonatal con MSG.
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ALTERACIONES INDUCIDAS.pdf-PDFA.pdf: 59025 bytes, checksum: 2ee91209b29002cf79f4e7f8729d4516 (MD5)
dc.title: Alteraciones inducidas por administración neonatal de monosodio L-glutamato (MSG) y su remisión mediante la administración de N-acetil cisteína
2016-04-01T00:00:00ZAsociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en ArgentinaSantos, María RitaRamallo, VirginiaMuzzio, MarinaLópez Camelo, Jorge SantiagoBailliet, Gracielahttps://digital.cic.gba.gob.ar/handle/11746/23362016-06-28T12:19:39Z2015-01-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 143; Revista Medica de Chile
dcterms.abstract: <strong>Background:</strong> NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP.<strong> Material and methods:</strong> We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT). Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio=1.6; p=0.03). Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP.
dc.description.*: Submitted by beatriz tosti (secretaria@imbice.gov.ar) on 2016-06-16T15:20:56Z workflow start=Step: CIC-ADMIN_review - action:claimaction
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dc.title: Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
2015-01-01T00:00:00ZAssociation between a Maternal History of Miscarriages and Birth DefectsCampaña, Hebe EdithRittler, MónicaGili, Juan A.Poletta, Fernando A.Pawluk, Mariela S.Giménez, Lucas G.Cosentino, Viviana R.Castilla, Eduardo E.López Camelo, Jorge Santiagohttps://digital.cic.gba.gob.ar/handle/11746/57832018-03-05T11:39:28Z2017-03-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 109, no. 4; Birth Defects Research Part A: Clinical and Molecular Teratology
dcterms.abstract: Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events.
The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed.
Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD.
Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias.
Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.
dcterms.publisher: John Wiley & Sons
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version enviada.pdf: 277798 bytes, checksum: bcb8c059bdad5d74d400bc51752a1eb6 (MD5); Step: CIC-ADMIN_review - action:editaction Approved for entry into archive by Silvia Peloche(silvia@sedici.unlp.edu.ar) on 2017-05-30T13:58:24Z (GMT); Made available in DSpace on 2017-05-30T13:58:24Z (GMT). No. of bitstreams: 1
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dc.title: Association between a Maternal History of Miscarriages and Birth Defects
2017-03-01T00:00:00ZAssociation between PER3 length polymorphism and onco-hematological diseases and its influence on patients functionalityCerliani, María BelénGili, Juan AntonioPavicic, Walter HernánKlein, GracielaSaba, SilviaRichard, Silvina Marielhttps://digital.cic.gba.gob.ar/handle/11746/22762016-06-16T17:55:42Z2015-01-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 1, nº 2; Advances in Modern Oncology Research
dcterms.abstract: Circadian clock gene PER3 and its length polymorphism may have a role in oncogenesis as clock genes act as key regulators of cell cycle and DNA repair pathways. The polymorphism may affect the condition of patients who show disrupted circadian rhythm due to tumor development. The aim was to assess the association between PER3 polymorphism and onco-hematological diseases, and analyze whether this variant has an impact on patient’s functionality.
We conducted a case-control study on 125 patients with onco-hematological diseases and 310 control patients. PER3 allelic variants were detected by using polymerase chain reaction. Sociodemographic data and information on patient’s habits and functionality were obtained through questionnaire. Genotypes 4/5 + 5/5 showed an odd ratio (OR) = 1.39, with no statistical significance. However, those genotypes were associated with a two-fold increase in the risk of acute/chronic lymphoblastic/myeloblastic leukemia, taken all together. The occurrence of “changes in humor during last two months” was significantly associated with onco-hematological diseases. “Fatigue on awakening” and “self-reported snore” were associated with cases carrying the 4/5 or 5/5 genotypes. The results suggested that PER3 polymorphism may have a role in the risk of leukemia, and might be a possible marker for individual differences in susceptibility to sleep disruption. This work provides insights for the identification of individuals at high risk of cancer, and those who are more susceptible to circadian disruption, which may decrease the physiological defenses against the tumor.
dcterms.publisher: PiscoMed Publishing
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dc.title: Association between PER3 length polymorphism and onco-hematological diseases and its influence on patients functionality
2015-01-01T00:00:00ZBrain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdomCabral, AgustinaDe Francesco, PabloPerelló, Mariohttps://digital.cic.gba.gob.ar/handle/11746/22782017-08-22T12:59:15Z2015-01-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 6, art. 44; Frontiers in Endocrinology
dcterms.abstract: The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain–blood barrier (BBB) imposes, the interplay between these two systems requires a variety of delicate anatomical interfaces and physiological mechanisms that guarantee the precise function of the neuroendocrine system as a whole. The study of the mechanisms by which hormones act in the brain in order to regulate specific neuronal populations is a research topic rather neglected. Our group studies the neuronal circuitries and molecular mechanisms by which the stomach-produced hormone ghrelin regulates appetite and other physiological functions. A clear notion of the brain targets of peripheral ghrelin is essential for the comprehensive understanding of the physiological role of this hormone. Ghrelin is called “the hunger hormone” since it is the only known orexigenic peptide hormone. The target for ghrelin orexigenic actions is the brain, which contains a variety of ghrelin-responsive nuclei; however, several evidences suggest that the accessibility of peripheral ghrelin to the brain is strikingly low. Here, we briefly summarize the current knowledge in this topic and discuss this intriguing neuroendocrinological issue.
dc.description.*: Submitted by beatriz tosti (secretaria@imbice.gov.ar) on 2016-06-21T13:35:36Z workflow start=Step: CIC-ADMIN_review - action:claimaction
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dc.title: Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
2015-01-01T00:00:00ZCharacterization and expression analysis of KIT and MITF-M genes in llamas and their relation to white coat colorAnello, MelinaDaverio, Maria SilvanaSilbestro, Miguel OsvaldoVidal Rioja, Lidia BeatrizDi Rocco, Florenciahttps://digital.cic.gba.gob.ar/handle/11746/106522020-08-06T20:02:23Z2019-04-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 50, no. 2; Animal Genetics
dcterms.abstract: The llama (Lama glama) is a fiber-producing species that presents a wide range of coat colors, among which white is one of the most important for the textile industry. However, there is little information about the molecular mechanisms that control the white phenotype in this species. In domestic mammals, a white coat is usually produced by mutations in the KIT proto-oncogene receptor tyrosine kinase (KIT) and microphthalmia-associated transcription factor (MITF) genes. In this work we have sequenced and described the coding regions of KIT and MITF-M, the melanocyte-specific isoform, and the two transcriptional variants MITF-M( ) and MITF-M(+). Moreover, we studied the expression of these genes in the skin of white and colored llamas. Although no variants were revealed to be associated with white coat color, significant differences between phenotypes were observed in the expression levels of KIT and MITF-M. Interestingly, white llamas expressed less MITF-M(+) than did colored ones, which is consistent with a consequent reduction in the synthesis of melanin. Even though our results indicate that downregulation of KIT and MITF-M expression is involved in white phenotype production in llamas, the causative gene of white coat color remains unknown.
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dc.title: Characterization and expression analysis of KIT and MITF-M genes in llamas and their relation to white coat color
2019-04-01T00:00:00ZCharacterization of smart auto-degradative hydrogel matrix containing alginate lyase to enhance levofloxacin delivery against bacterial biofilmsIslan, G.Dini, C.Bartel, L.Bolzan, Agustín EduardoCastro, G.https://digital.cic.gba.gob.ar/handle/11746/42662017-09-06T13:15:27Z2015-01-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: vol. 496; International Journal of Pharmaceutics
dcterms.abstract: The aim of the present work is the characterization of smart auto-degradable microspheres composed of calcium alginate/high methoxylated pectin containing an alginate lyase (AL) from<em>Sphingobacterium multivorum</em>and levofloxacin. Microspheres were prepared by ionotropic gelation containing AL in its inactive form at pH 4.0. Incubation of microspheres in Tris–HCl and PBS buffers at pH 7.40 allowed to establish the effect of ion-chelating phosphate on matrix erodability and suggested an intrinsically activation of AL by turning the pH close to neutrality. Scanning electron and optical microscopies revealed the presence of holes and surface changes in AL containing microspheres. Furthermore, texturometric parameters, DSC profiles and swelling properties were showing strong changes in microspheres properties. Encapsulation of levofloxacin into microspheres containing AL showed 70% efficiency and 35% enhancement of antimicrobial activity against<em>Pseudomonas aeruginosa</em>biofilm. Levofloxacin release from microspheres was not changed at acidic pH, but was modified at neutral pH in presence of AL. Advantageously, only gel matrix debris were detectable after overnight incubation, indicating an autodegradative gel process activated by the pH. Absence of matrix cytotoxicity and a reduction of the levofloxacin toxicity after encapsulation were observed in mammalian CHO-K1 cell cultures. These properties make the system a potent and versatile tool for antibiotic oral delivery targeted to intestine, enhancing the drug bioavailability to eradicate bacterial biofilm and avoiding possible intestinal obstructions.
dc.description.*: Submitted by beatriz tosti (secretaria@imbice.gov.ar) on 2016-06-16T16:09:02Z workflow start=Step: CIC-ADMIN_review - action:claimaction
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Islan Bolzán Castro - Characterization of smart.pdf-PDFA.pdf: 1933974 bytes, checksum: d596fcef9802dff22a246e6128d40279 (MD5)
dc.title: Characterization of smart auto-degradative hydrogel matrix containing alginate lyase to enhance levofloxacin delivery against bacterial biofilms
2015-01-01T00:00:00ZChronic Glucocorticoid-Rich Milieu and Liver DysfunctionVillagarcía, Hernán GonzaloSabugo, VanesaCastro, María CeciliaSchinella, Guillermo RaúlCastrogiovanni, DanielSpinedi, EduardoMassa, María LauraFrancini, Flaviohttps://digital.cic.gba.gob.ar/handle/11746/70172018-09-30T04:01:47Z2016-01-01T00:00:00Zdc.type: Artículo
dcterms.isPartOf.*: volumen 2016; International Journal of Endocrinology
dcterms.abstract: We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs)were increased. In conclusion adultMSGrats developed an insulinresistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis.These features, shared by both metabolic and Cushing’s syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis.
Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation.
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dc.title: Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
2016-01-01T00:00:00Z